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12 Articles in Volume 7, Issue #8
A Clinical Guide to Weaning Off Intrathecal Opioids
Avoiding the Pitfalls of Opioid Reversal with Naloxone
Central Role of Dopamine in Fibromyalgia
CES in the Treatment of Insomnia: A Review and Meta-analysis
Combined Phrenic Nerve Palsy and Cervical Facet Joint Pain
Dextrose Prolotherapy for Unresolved Neck Pain
Low Level Laser Therapy - Part 1
Mistakes Made by Chronic Pain Patients
Near-infrared Therapeutic Laser and Pain Relief
Patulous Eustachian Tube: Part 2
The “Promise” of Pain Medicine: Profession, Oaths, and the Probity of Practice
Three Dimensional Imaging of the Foot

CES in the Treatment of Insomnia: A Review and Meta-analysis

Cranial Electrotherapy Stimulation (CES) is an effective, established treatment for insomnia that avoids polypharmacy interactions for pain patients taking medications while simultaneously reducing anxiety, depression, and pain.

Primary insomnia is a complaint lasting for at least one month, of difficulty initiating and/or maintaining sleep or of the presence of nonrestorative sleep as defined by the Diagnostic and Statistical Manual of Mental Disorders.1 Primary insomnia is categorized as a Primary Sleep Disorder, under the category of “Dyssomnias” in the DSM-IV-TR. The diagnostic criteria for primary insomnia is summarized in Table 1.2

The International Classification of Sleep Disorders Revised (ICSD-R) uses the term “psychophysiologic insomnia” for a complaint of insomnia, and for the associated decreased functioning during wakefulness. The ICSD-R defines insomnia of six months duration as chronic.3

The DSM criteria also reflects the now widely-accepted use of polysomnography (PSG) which has enlarged the scope of differential diagnosis when assessing insomnia. The DSM-IV-TR categorizes all sleep disorders as either dyssomnias or parasomnias.4 Parasomnias include diagnoses of Nightmare Disorder, Sleep Terror Disorder, Sleep-walking Disorder, or “not otherwise specified” conditions such as REM sleep behavior disorder and sleep paralysis. Sleep paralysis can be an exaggeration of a relatively nonpathologic hypnagogic event, or can be a common component of Narcolepsy, which itself is one of the dyssomnias. A list of some common dyssomnias is shown in Table 2.

Estimates of the number of people in the U.S. who suffer from insomnia range from 18 million to 24 million in adulthood, and up to 20% in later life, or 7 million in people 65 years of age and older, with women being about two times as likely to develop insomnia as men.5,6

Theoretically, “nonrestorative” or nonrefreshing sleep is definable as some impairment in daytime functioning but is not always easy to demonstrate clinically. It has been difficult to demonstrate systematic impairment of daytime function in insomniacs. Some PSG studies have shown clear differences between the sleep of insomniacs and normal subjects.7 However, there is one large study which shows extensive overlap in PSG indicators of sleep between insomnia patients and normal controls.8 So controversy exists whether patients with insomnia complaints and response to hypnotics differ from controls in any PSG measures of sleep and daytime function.9

Table 1. DSM-IV-TR Diagnostic Criteria for Primary Insomnia
A. Difficulty initiating or maintaining sleep, or nonrestorative sleep, for at least one month
B. Sleep disturbance (or associated daytime fatigue) causes clinically significant distress or impairment in social, occupational, or other important areas of functioning
C. Sleep disturbance does not occur exclusively during the course of Narcolepsy, Breathing-Related Sleep Disorder, Circadian-Rhythm Sleep Disorder, or a Parasomnia
D. Sleep disturbance does not occur exclusively during the course of another mental disorder such as Major Depressive Disorder, Generalized Anxiety Disorder, or a delirium.
E. The disturbance is not due to the direct physiological effects of a substance (such as a drug of abuse or a medication) or a general medical condition

The significance of insomnia also relates to whether it occurs at the beginning, the end, or in the middle of the course of the usual sleep period. Traditionally, insomnia has been classified into three main types: delayed sleep onset, impaired sleep continuity, and early-morning awakening.10 Insomnia can be a feature of many major psychiatric disorders but is not regarded as a necessary diagnostic criterion for any particular disorder. Insomnia can be the sole symptom of depression, and can be a risk factor for the development or recurrence of some psychiatric disorders. Paradoxically, sleep loss can be both a symptom and a treatment of major depression.11

The primary function of sleep is to ensure adequate cortical function when awake.12 According to one theory, two processes interact in normal sleep production. The sleep homeostat drives the sleep-wake schedule toward a balanced requirement (prolonged wakefulness incurs a “sleep debt”), and an internal circadian timer regulates the 24 hour biological clock’s sleep-wake cycle.13 Together, the two processes regulate not only the amount of sleep but the quality of sleep as well. The two processes also differ across the life span, with young children requiring longer periods of sleep with more rapid eye movement (REM) sleep than do adults as the homeostatic drive declines with age.14

There is no absolute technique for falling asleep and staying asleep. Sleep is generally regarded as a passive process in which internal and external cues enable autonomic conditions for sleep. According to the inhibition model, there is both a physiological de-arousal, and a cognitive de-arousal, allowing sleep to occur.15,16

Table 2. Listing of DSM-IV-TR Main Dyssomnias
A. 307.42 Primary Insomnia
B. 307.44 Primary Hypersomnia
C. 347.00 Narcolepsy
D. 780.57 Breathing-Related Sleeping Disorder
E. 327.xx Circadian Rythm Sleep Disorder
.31 Delayed Sleep Phase Type
.35 Jet Lag Type
.36 Shift Work Type

Sleep will usually not occur during cognitive arousal. According to Freud, the first step in becoming an insomniac is to worry that one will not sleep when one goes to bed. Recent research has borne out the fact that worries of any kind—but certainly a fear of not falling asleep and worrying about the resulting consequences of this for one’s life the next day—clearly deactivates the cognitive de-arousal required for sleeping.17

When asked what kinds of thoughts they have when they attempt to sleep, insomniacs provide a long list, typically including planning, thinking things out—especially with a negative emotional content, fear of not sleeping, plus concentrating on worrisome changes that are operative in their lives. When people who have no problems falling asleep are asked what they think about when they go to bed at night, many answer, “nothing especially.”

While medications are often used to treat insomnia, those in the class of benzodiazepine and related chemical structures have limited usefulness over the long range since they tend towards tachyphylaxis (rapidly decreasing response following initial doses) and produce tolerance. The use of cognitive behavior therapy for enhancing sleep is often suggested since it may identify the things that the insomniac is doing to defeat the brain’s attempt to de-arouse.18

People also sleep poorly due to illnesses, especially pain, depression, chronic medication effects, sleep apnea, anxiety, other stress related disorders, and other sleep disorders that can be diagnosed with PSG. These should all be addressed and evaluated as part of any therapy that is provided to the insomniac.

Of additional interest in electromedicine is that the head in the awake person has a negative ionic charge anteriorly and a positive ionic charge posteriorly. Those charges reverse, both when the person is asleep, and when under general anesthesia. The person whose head remains negative anteriorly will not sleep well until such electrical conditions reverse.19

Treating Insomnia with CES

Cranial electrotherapy stimulation (CES) is the FDA recognized generic category for medical devices using microcurrent levels of electrical stimulation applied across the head via transcutaneous electrodes for the treatment of anxiety, insomnia, and depression. Ear clip electrodes, moistened with an appropriate conducting solution, are applied for 20 minutes to an hour or more on an initial daily basis for a week or two, followed by a reduced schedule of 2 or 3 treatments a week until the insomnia is resolved, and then further reduced to an as-needed (p.r.n.) basis.

When CES first came to the U.S.A. in the 1960s it was called “Electrosleep.” The intent of electrosleep was to put patients to sleep when the current was turned on. That rarely occurred regardless of the waveform parameters.

Confirming Kratzenstein’s observation in 1743 that putting electricity in his body during the day helped him sleep at night,20 research has revealed that CES, while not directly inducing sleep, helps to improve the quality of night time sleep, regardless of what time of day CES is used.

Figure 1. The results of a double blind CES study on insomnia, with two year follow up. While the sham group did improve over the two year period except in restoration (feeling rested in AM), the treatment group did significantly better in all areas and those effects were maintained or improved at follow up

In one study, ten patients were allowed to sleep in a sleep lab that monitored their EEG overnight. Half were given CES and half were given sham CES. After 30 minutes of stimulation daily for ten days, it was found that those patients receiving actual CES went to sleep faster, awoke fewer times during the night, spent more time in Stage IV sleep, and reported feeling more rested the following morning. At two year follow up, the CES treated patients were still sleeping normally, while the sham treated patients were not, as shown in Figure 1.21,22

To understand insomnia, we need to understand the distinction between the different stages of sleep, which are studied using polysomnography (PSG) and electroencephalography (EEG). PSG is a combination of multiple channels of neurophysiologic information. An 18 channel device might typically include six channels of scalp EEG, two channels of left and right eye movements, electrocardiogram (ECG), 2-3 channels of electromyogram (EMG), oxygen saturation, and other channels representing movements of the mouth, chest, and abdomen. EEG examinations usually involve a larger number of EEG channels but may also contain ECG, and some of the other PSG-type information detailed above as well as photic stimulation recording and intranasal or sphenoid electrodes for special localization studies.

Brain wave frequencies and the presence or absence of REM sleep have been used to divide sleep into two broad categories.23 Rapid eye movements (REM) were defined as “regularly recurrent periods of altered ocular motility during sleep.” This prompted a dichotomy of two different types of sleep: (1) Non-REM (“slow sleep”) and (2) REM sleep (“paradoxical sleep” or “fast sleep”).

The basic brain wave frequencies are of course the same in both EEG and PSG, but the look and feel of the recordings is quite different. The brain waves are grouped into four frequency bands of cycles per second, or Herz (Hz): (1) Delta: under 4 Hz, (2) Theta: 4-7 Hz, (3) Alpha: 8-13, and (4) Beta: 14 Hz and above. The modern terminology of four sleep stages includes (1) Drowsiness, (2) Light sleep, (3) Deep sleep, and (4) Very deep sleep.24 Sleep stages have both clinical and electrographic correlates. In Stage I, in which there is a feeling of drowsiness, the alpha rhythm becomes flatter, a dropout of the higher frequencies occurs, and, some theta frequencies begin to appear in the electrodes that cover the vertex of the skull. Stage II is characterized as light sleep, theta waves predominate instead of alpha waves, and the EEG recording shows the same vertex waves, and other electrographic structures called “sleep spindles” and “K-Complexes.” Stage III is a deeper stage of sleep. The EEG record shows much slowing, and theta and delta waves (0-4 Hz) predominate while the record continues to show some of the same electrographic structures seen in Stage II. Stage IV is the deepest and most restful stage of sleep. High amplitude, low-frequency delta waves predominate. Conventional EEG lab studies usually do not show this stage because the recordings are usually less than one hour in duration and it often takes more than one hour to go into Stage IV sleep.

CES Research

Research has revealed that a series of CES treatments not only facilitates sound, restful sleep, but can effectively treat stress in the process, as measured by various psychometric scales of depression and anxiety.

Feighner studied 21 long term insomniacs and employed a global rating scale of sleep. From the change in sleep pattern observed, a two-tailed t test of probability result was obtained at the .0002 level. As this study utilized a crossover design, this change was computed on the first group of treated patients prior to the crossover.25

Flemenbaum studied 28 outpatients who had suffered from insomnia for 3 to 4 years. They were provided with five, 30 minute CES treatments. The results, scored on a global rating scale, indicated a 50% improvement in their sleep und that persisted six months later.26

Frankel added a most unusual study to the CES insomnia literature in that half of the patients were treated with 100 Hz, while the other half were treated with 15 Hz. The two groups were then subjected to a crossover. It was never explained why those two different frequencies were chosen and, in the data analysis, why they were never broken down separately. He combined data from both the 100 Hz and 15 Hz patients before the crossover, then again following the crossover so that any treatment effects from either frequency could not be ascertained separately.27

Gomez studied self withdrawal from methadone maintenance with 28 heroin addicts in a VA hospital. It was discovered that the treated patients, but not the controls, significantly reduced their PRN sleep medication requests beginning the third night of the ten day treatment.28

Hearst gave 28 psychiatric outpatients five 30 minute CES treatments or sham treatments, and had both physicians and the patients complete a global rating of sleep. The treated patients scored 42% higher than did the controls on sleep improvement.29

Hozumi studied a group of 27 inpatients with multi-infarct dementia, giving them either real or sham CES for 20 minutes daily for two weeks. They found that in addition to significantly improving their sleep, CES was significantly effective in improving sleep related behavioral disorders such as nocturnal wandering and nocturnal delirium.30

Kirsch compiled physicians’ ratings for 500 patients treated with Alpha-Stim CES. Within this group, 135 complained of persistent sleep problems, and although they were treated for various lengths of time, 79% said they had experienced significant improvement of 25% or greater. The average improvement among the overall group was 62%.31

Lichtbroun did two double-blind studies of fibromyalgia patients who customarily have very poor sleep. Following one hour of actual CES daily for three weeks, the first group of 30 improved 72%. Following the same treatment protocol, the second 60 patients rated their sleep as being 82% improved, while there were no significant changes in the sham treated groups.32,33

Figure 2. Sleep patterns in fibromyalgia patients showing improvement from subsensory CES in the double blind group, and “sensate” CES in the sham group after they were crossed over to an open clinical trial.

Figure 2 shows the sleep patterns in this 60-subject Alpha-Stim CES fibromyalgia study.33 It can be seen that the sleep of CES-treated patients improved greatly both during the subsensory double-blind phase of the study and following the one way crossover where the sham treated controls self-treated with CES at home above the subsensory level using the normal protocol to regulate treatment time and current level. The graph in Figure 2 also indicates that the stronger stimulus levels used in the crossover open clinical trial phase achieved better sleep results than with subsensory stimulation. This would be more consistent with actual clinical practice results than with the restricted subsensory current level used in double-blind research.

Moore gave 17 patients five days of CES, 30 minutes per day in a crossover design. The first group to get treatment prior to the crossover reported a 46% improvement on self rated sleep scales.34

Patterson published two CES studies that address insomnia. One was a seven year retrospective review of 186 addicts and the other was a small 18 patient study of addicts. Sleep improvement of 56% was found in the first group, and 55% in the second group.35,36

Philip withdrew patients from anti-depressant medication so they could be given electroconvulsive therapy (ECT). CES was successfully used to withdraw from the drugs for one week. Philip was totally unaware of the ability of longer term CES to effectively treat depression, so while the patients got through their drug abstinence period successfully with 42% better sleep, they were still given ECT.37

Rosenthal completed three studies with 9, 18, and 22 patients respectively, in which a clinical rating scale was used to assess changes in sleep behavior. Patients were treated for 30 minutes a day for five days with CES or sham CES. CES treated patients in these studies experienced 50%, 60% and 81% sleep improvement.38-40

Straus gave CES or sham CES to 34 inpatients who suffered from insomnia, and compared the effects of CES with phenobarbital for inducing sleep. Sleep improved among the CES-treated patients over the one to two week treatment period approximately 33%. In this study CES was found to be as efficacious as phenobarbital in inducing sleep, but without the adverse side effects.41

Tyers completed two studies with fibromyalgia patients. He gave them CES for one hour a day for three weeks. A ten point self-rated sleep questionnaire was completed pre- and post-study. Results of one study of 20 severe pain patients showed that sleep improved 79% on average, while sleep of 56 patients in the second study improved by 53%.42,43

Three hundred surveys had been sent in by patients diagnosed with insomnia. In this group, Alpha-Stim CES had been used for a minimum of three weeks. Patient responses were analyzed to assess their perception of CES’s effectiveness in the treatment of their sleep disorder.44 Among the people who listed insomnia as a major diagnosis were those who also included comorbidities such as anxiety or depression, while still others listed pain as their major accompanying symptom. The results were broken down into several subcategories of insomnia as shown in Table 3, where it can be seen that patients reported an average of 87% improvement.


Table 4 lists the studies that have been found in which CES was used to treat insomnia.

Meta-analysis is a statistical method of combining the results of several studies that address a set of related research hypotheses. Our meta-analysis of CES calculates the percent of patients improving versus the percent not improving to yield the treatment effect size r, which is equal to the amount of patient improvement given as percentage. These results can be compared with the accepted standardized ratings of r = .10 for small effect, r = .30 for medium effect and r =.50 for large effect. Table 5 shows a meta-analysis of the studies in Table 4, minus the study by Frankel that did not present treatment results prior to the crossover, and therefore could not be used. All resulting data were converted to Zr scores as previously described for the purpose of combining the effects from the various studies.45,46

Table 3. Patient’s Self-reported Results from Using CES
Three Weeks or More
Diagnosis Number %Female Age Weeks Used Improvement

Insomnia only

69 59% 3 – 81 yrs
47.86 yrs
0 – 52 wks
6.79 wks
0 – 99%

Insomnia & Anxiety and/or Depression

24 – 86 yrs
49.37 yrs
1 – 28 wks
5.71 wks
0 – 100%

Insomnia & Pain

143 78% 21 – 85 yrs
50.66 yrs
0 – 78 wks
9.68 wks
1% - 99%

Total Insomnia

300 68% 3 – 86 yrs
49.66 yrs
0 – 78 wks
7.95 wks
0 – 100%
Mean Effect Size: r = .87

The summary at the end of Table 5 indicates that the mean effect size from all 20 studies combined (7 of which were double blind), was a strong r = .64. The standard deviation, or distribution of effect sizes around the mean effect size was .36, so 99% of effect sizes gained from all future meta-analyses will be expected to fall between r = .41 and r = .87 (the confidence interval). Clearly, CES can be an effective treatment for insomnia, with the added benefit that it has minimal negative side effects, it is less expensive than medications and has no cross-reactions with the plethora of medications used for insomnia, and can be used over a long period of time without becoming addictive.

Table 4. List and Description of Insomnia Studies
Author Primary Diagnosis Patient Therapist Assessor Study Design Outcome Measure
Feighner25 Insomniacs Yes No Yes Crossover 2 wks/2 wks Global Rating Scale
Flemenbaum26 Insomniacs No No No Open Clinical Clinical Rating Scale
Frankel27 Insomniacs No No No Crossover 3 wks/3 wks Psychology Tests/Biochem
Gomez28 Drug Abstinence Syndrome Yes No No Single Blind PRN Medication
Hearst29 Insomniacs Yes No No Single Blind Clinical Rating Scale
Hozumi30 Multi-InfarctDementia Yes ? ? Double Blind EEG/Clinical Rating Scale
Kirsch31 Insomniacs No No No Post Treatment Physician Survey Physician’s Rating
Lichtbroun32 Fibromyalgia Yes Yes Yes Double Blind Placebo Controlled Self Rating Scale
Lichtbroun33 Fibromyalgia Yes Yes Yes Double Blind Placebo Controlled Self Rating Scale
Moore34 Insomniacs Yes No Yes Crossover 1 wk/1wk Self Rating Scale
Patterson35 Drug Abstinence Syndrome No No Yes Post Rx Physician Survey Clinical & Self Rating Scales
Patternson36 Drug Abstinence Syndrome Yes Yes Yes Double Blind Clinical Rating Scale
Philip37 Drug Abstinence Syndrome Yes Yes No Double Blind Self Rating Scale
Rosenthal38 Insomniacs No No No Open Clinical Clinical Rating Scale
Rosenthal39 Insomniacs Yes No No Single Blind Clinical Rating Scale
Rosenthal40 Insomniacs Yes No Yes Double Blind Clinical Rating Scale
Smith44 Insomniacs No No No Patient Self Report Survey Self Rating Scales
Straus41 Insomniacs Yes No Yes Crossover 2wk/2wk Clinical Rating Scale
Tyres42 Fibromyalgia No No No Open Clinical Self Rating Scale
Tyres43 Fibromyalgia No No No Open Clinical Self Rating Scale
Weiss21 Insomniacs Yes Yes No Double Blind EEG/Self Rating Scale


There have been more than 20 sleep studies done with CES for insomnia as the primary diagnosis or as a secondary diagnosis to addictions or other forms of stress or pain related disorders. These studies demonstrate that CES can be an excellent treatment for insomnia in those patients who can accept and adapt to the modality. CES also has the additional benefit of helping to reduce dependence on drugs.37

When the problem of studies done with a crossover design is counteracted by utilizing the results prior to the first crossover, Frankel conducted the only study in the CES literature that appears to have demonstrated no benefits of CES for insomnia, and this result very likely is due to experimental design difficulties.

Frankel described his group as suffering from “primary insomnia,” and that has proven confusing. In fact, he recruited subjects from newspaper advertisements seeking people who had trouble sleeping. Weiss selected his subjects in exactly the same way, and yet obtained very robust results, that held up over a 24 month follow up period.21,22

Several studies have been included in which stimulation was given for only 30 minutes for five days, along with studies that provided one hour of stimulation for three weeks. No attempt has been made to separate out those two ends of the treatment spectrum to see if there is additional benefit from longer periods of treatment. The primary reason is that not separating them can be viewed as a conservative meta-analysis strategy. Even when including all these studies in a meta-analysis, CES emerges as a very robust treatment for insomnia. Finally, as with all meta-analyses, a statistical check was made to test for heterogeneity of variance, and none was found, meaning that those treated for one week were not statistically distinct from those treated for longer periods of time. This suggests that one week of CES is quite possibly all that is required to initiate a significant improvement in this debilitating disorder, at least for some patients. Others, especially those with comorbidities may need considerably longer treatment to produce a sustained effect; possibly as much as two months of daily treatment.

Clinical Procedures and Considerations

CES may result in very vivid dreams, especially in post traumatic stress disorder patients. It is best to warn patients of this. Some individuals may panic after using CES for the first time in the mistaken belief that CES is adversely affecting them. They report having extremely vivid dreams and erroneously conclude that something must be going wrong. On the other hand, those who have been warned in advance are able to relax and enjoy the experience—only regretting it when their dreams return to normal after the first week or two.

A small percentage of people cannot use CES prior to going to sleep since it also induces an alert state of mind that can cause some people to remain wide awake because of their stimulated thought processes. On the other hand, the vast majority of people have better results using CES within three hours of going to sleep. If they wake up during the night they can remoisten the electrodes and turn the device back on for another treatment. This typically causes them to resume sleeping. A problem can occur after their sleep is normalized, usually by the end of the first or second week of use. If they continue to use CES immediately prior to sleep, a paradoxical alerting reaction may occur that again, could cause alertness instead of helping them sleep. At that point it is best to defer CES usage to the morning, and no more than two or three times per week.

Patients who are trying to eliminate benzodiazepines should do so very slowly, of course, and under the supervision of their physician because of withdrawal-induced insomnia and anxiety symptoms. CES will stimulate endorphin production,47 but it can take a few days for the endorphin level to elevate sufficiently to modulate the norepinephrine in the brain, so the patient will be more agitated (and alert) during these few days. Sleep will worsen accordingly. The patient should be counseled regarding this process and encouraged to wait it out. It will certainly help if the drug is withdrawn slowly over weeks, using CES to help the brain normalize as the drug is withdrawn. As CES has been shown to potentiate the uptake and utilization of psychoactive medications, it may be prudent to reduce any ongoing sleep medication by at least one-third when CES is being added to pharmaceutical regimens.48,49 However, any long-term or short-term reduction of medications requires active participation of the patient in making this decision. Following this pattern will enhance the patient’s sense of well-being as well as a sense of control over two different disturbing problems: the insomnia as well as the challenging medications often used to treat insomnia.

In addition to CES, cognitive behavioral therapy (CBT) is another treatment modality that may offer clear advantages over medications.50 One study randomly treated 48 chronic insomniacs with CBT, Zopiclone (similar to Lunesta), or inactive placebo for six weeks. At the end of treatment and then six months later, sleep records (ambulatory PSG used in the home bedroom setting) were obtained. The authors stated, “For most outcomes, zopiclone did not differ from placebo...patients receiving CBT had better sleep efficiency using polysomnography than those taking zopiclone.” Another source paraphrased the study as, “CBT raised the patients’ average slow-wave sleep 27 percent by the end of treatment, and had increased it 34 percent six months later. Patients who took the sleeping pill had a big drop in the amount of slow-wave sleep. They had 20 percent less slow-wave sleep at the end of treatment, and six months later, they had 23 percent less slow-wave sleep.”51

Table 5. Meta-analysis of CES Insomnia Studies Shown in Table 4.
  Number of Patients    
Author CES Sham Total Statistic Reported Zr Equiv-alent
Feighner 10 9 19 59% Imp .678
Flemenbaum 28 none 28 P<.01 .511
Gomez 14 14 28 93% Imp. 1.650
Hearst 14 14 28 42% Imp. .448
Hozumi 14 13 27 P<.05 .388
Kirsch 135 none 135 62% Imp 725
Lichtbroun 10 20 30 72% Imp .908
Lichtbroun 20 40 60 82% Imp .875
Moore 17 17 34 P<.05 .343
Patterson 186 none 186 56% Imp .633
Patterson 8 10 18 P<.02 .590
Philip 10 11 21 P<.05 .448
Rosenthal 9 none 9 50% Imp .549
Rosenthal 12 6 18 60% Imp .693
Rosenthal 11 11 22 81% Imp 1.127
Smith 300 none 300 87% Imp .811
Straus 17 17 34 P<.05 .343
Tyres 20 none 20 79% Imp 1.071
Tyres 60 none 56 53% Imp .590
Weiss 5 5 10 P<.001 1.528


900 187 1083   14.909
Mean .746
Effect Size r = .64
Standard Deviation .36
Standard Error of the Mean .08
Confidence Interval, p<.01, r = .41 to r = .87

In tandem with CES, CBT may also offer clear advantages for some patients over soporifics and hypnotic medications used to promote sleep (Table 6). The concomitant use of CES, a neuroelectric modality, and CBT, a behaviorally-oriented form of psychotherapy gives the physician an even wider potential range of clinical effectiveness for dealing with insomnia. When possible, combining CES and CBT can facilitate less continuous and therefore more effective application of soporific and hypnotic medications. Intermittent use of hypnotics minimizes the negative consequences of adding tolerance and addiction to the problems of insomnia.

Last updated on: January 24, 2012
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