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6 Articles in Volume 1, Issue #3
Breaking Down the Barriers of Pain: Part 3
CES: A Practical Protocol for theTreatment of Pain
New Directions
Pharmaceutical Therapies
The Neural Plasticity Model of Fibromyalgia Theory, Assessment, and Treatment: Part 1

CES: A Practical Protocol for theTreatment of Pain

The final installment of this series covers cranial electrotherapy stimulation as a means of treating pain patients.

Cranial electrotherapy stimulation (CES) is the application of low-level, pulsed electrical currents (usually not exceeding one milliampere), applied to the head for medical and/or psychological purposes. It is primarily used to treat both state (situational) and trait (chronic) anxiety, depression, insomnia, stress related and drug addiction disorders, but it is also proving indispensable for treating pain patients.1-3

Drs. Leduc and Rouxeau of France were first to experiment with low intensity electrical stimulation of the brain in 1902. Initially, this method was called electrosleep as it was thought to be able to induce sleep. Since then, it has been referred to by many other names, the most popular being transcranial electrotherapy (TCET) and neuroelectric therapy (NET). Research on using what is now known as cranial electrotherapy stimulation (CES) began in the Soviet Union during the 1950s.

CES is a simple treatment that can easily be administered at any time. The current is applied by easy-to-use clip electrodes that attach on the ear lobes, or by stethoscope-type electrodes placed behind the ears. In the 1960s and early 1970s, electrodes were placed directly on the eyes because it was thought that the low level of current used in CES could not otherwise penetrate the cranium. This electrode placement was abandoned more than 20 years ago. Recent research has shown that from 1 mA of current, about 5 µA/cm2 of CES reaches the thalamic area at a radius of 13.30 mm which is sufficient to affect the manufacture and release of neurotransmitters.4

Most cranial electrotherapy stimulators are limited to 600 µA at 9 volts (0.0054 watts). To put this in perspective, this is about 11,000 times less energy output than a 60 watt bulb. Some people do not even feel this small amount of current.

Therapeutic effects are usually experienced during a treatment, but may be seen hours later, or as late as one day after treatment. Some people require a series of five to 10 daily treatments before an effect is seen. In severe depression CES may take up to three weeks to establish a therapeutic effect.

CES leaves the user alert while inducing a relaxed state. Most people experience a feeling that their bodies are lighter, while thinking is clearer and more creative. A mild tingling sensation at the electrode sites may also be experienced during treatment, and therefore, current should never be raised to a level that is uncomfortable. One 20-minute session is often all that is needed for at least a day, and the effects are usually cumulative. If the patient can only tolerate a small amount of current (5 For people who have difficulty falling asleep, CES should be used in the morning to avoid the possibility of increased alertness that may interfere with sleep.

Most people can resume normal activities immediately after treatment. Some people may experience an euphoric feeling, or a state of deep relaxation that may temporarily impair their mental and/or physical abilities for the performance of potentially hazardous tasks, such as operating a motor vehicle or heavy machinery, for up to several hours after treatment.

At present, there are more than 100 research studies on CES in humans and 20 experimental animal studies.5 No significant lasting side effects have ever been reported, but occasional self-limiting headache (one out of 450), discomfort or skin irritation under the electrodes (one out of 811), or lightheadedness may occur. A rare patient with a history of vertigo may experience dizziness for hours or days after treatment.

As in many areas of biology and therapy, the evidence of CES effectiveness is empirical. It is generally believed that the effects are primarily mediated through a direct action on the brain at the limbic system, the hypothalamus, and/or reticular activating system.6-8 The primary role of the reticular activating system is the regulation of electrocortical activity. Electrical stimulation of the periaqueductal gray matter has been shown to activate descending inhibitory pathways from the medial brainstem to the dorsal horn of the spinal cord, in a manner similar to b-endorphins.9-11 Cortical inhibition is a factor in the Melzack-Wall Gate Control theory.12 Toriyama suggested it is possible that CES may produce its effects through parasympathetic autonomic nervous system dominance via stimulation of the vagus nerve (CN X).13 Taylor added other cranial nerves such as the trigeminal (CN V), facial (CN VII), and glossopharyngeal (CN IX).14 Fields showed that electrocortical activity produced by stimulation of the trigeminal nerve is implicated in the function of the limbic region of the midbrain affecting emotions.15 Substance P and enkephalin have been found in the trigeminal nucleus, and are postulated to be involved in limbic emotional brain structures.16 The auditory-vertigo nerve (CN VIII) must also be effected by CES, accounting for the dizziness one experiences when the current is too high. Ideally, CES electrodes are placed on the ear lobes because that is a convenient way to direct current through the midbrain and brain stem structures.

From studies of CES in monkeys, Jarzembski measured 42 to 46 percent of the current entering the brain, with the highest concentration in the limbic region.17 Rat studies by Krupisky showed as much as a threefold increase in b-endorphin concentration after just one CES treatment.18 Pozos conducted mongrel dog research that suggests CES releases dopamine in the basal ganglia, and that the overall physiological effects appear to be anticholinergic and catecholamine-like in action.19 Richter found the size, location, and distribution of synaptic vesicles all within normal limits after a series of 10, one-hour treatments in Rhesus monkeys.20 Several studies in stump-tailed macaques and humans revealed a temporary reduction in gastric hypersecretion.21-24

A recent review by Kirsch of 106 human studies involving 5,439 subjects (4,058 receiving CES, while the remainder served as sham-treated or placebo controls)5 revealed significant changes associated with anxiolytic relaxation responses, such as lowered reading on electromyograms,7,25-28 slowing on electroencephalograms,29-35 increased peripheral temperature, an indicator of vasodilatation,6,26 reductions in gastric acid output,24 and in blood pressure, pulse, respiration, and heart rate.14,26

The efficacy of CES has also been clinically confirmed through the use of 27 different psychometric tests. The significance of CES research for treating anxiety has been reconfirmed through meta-analyses conducted at the University of Tulsa by O'Connor, and by Klawansky at the Department of Health Policy and Management, Harvard School of Public Health.36-37

Sixteen studies conducted follow-up investigations from one week to two years after treatment.6,26,38-51 All 16 reported that at least some of the subjects had a continued improvement after a single CES treatment, or a series of CES treatments. None of these 16 studies revealed any long term harmful effects.

CES has been well researched and clearly proven to be a highly efficacious and safe method of treatment for anxiety, and anxiety-related disorders. It is also efficacious for depression and insomnia, muscle tension, fibromyalgia, and headaches. As an increasing number of patients seek alternatives to the side effects and potential addiction to pharmaceuticals and controlled substances, CES offers a viable solution. It is easy enough to offer CES in the practice. In addition, chronically-stressed patients may find it cost-effective over time to own their own CES devices.

Cranial electrotherapy stimulation (CES) is a simple treatment that can easily be administered at any time


In addition to the primary claims for anxiety, depression insomnia, and pain, CES has been researched with significant results for many other conditions. Smith and Shiromoto showed it to be highly effective in blocking fear perception in phobic patients.52 Favorable results have also been reported for labor, epilepsy, hypertension, surgery, spinal cord injuries, chronic pain, arthritis, cerebral atherosclerosis, eczema, dental pain, asthma, ischemic heart disease, stroke, motion sickness, digestive disorders as well as various addictive disorders including cocaine, marijuana, heroin, and alcohol abuse.27,38,53-60

Reflex sympathetic dystrophy (RSD) and fibromyalgia syndrome (FMS) are two significant pain diagnoses from primary central and autonomic nervous system etiologies that respond best to CES.1,61 Adding somatic treatment with MET to these two conditions does not seem to improve the outcomes.

Besides specific pathological disorders, there are a growing number of studies being conducted that show increases in cognitive functions. Michael Hutchison discussed several mind enhancement techniques in his popular book, Mega-brain, devoting chapter nine to CES as a tool for attaining higher levels of consciousness.62 Sparked by Hutchison, Madden and Kirsch completed a study that demonstrated CES to be a useful tool for improving psychomotor abilities.8 Smith recently demonstrated that CES significantly improved attention deficit disorder (ADD) after only three weeks of treatment, and maintained the effect through an 18-month follow-up assessment.49


CES devices are generally similar in size and appearance to TENS units, but produce very different waveforms. Standard milliampere-current TENS devices must never be applied transcranially. CES electrodes can be placed bitemporally, forehead to posterior neck, bilaterally in the hollow just anterior to the mastoid processes, or through electrodes clipped to the earlobes. The ear clip method is the easiest and possibly most effective electrode placement.

The electrodes must first be wet with an appropriate conducting solution. When using ear clip electrodes, apply them to the superior aspect of the ear lobes, as close to the jaw as possible. Start with a low current and gradually increase it. If the current is too high the patient may experience a painful stinging sensation at the electrodes, dizziness, or nausea. If any of these three symptoms arise, immediately reduce the current and the symptoms will subside in a few moments. After a minute or two, try increasing the current again, but keep it at a comfortable level. It is okay for the patient to feel the current as long as it is not uncomfortable.

The ideal treatment time is 20 to 60 minutes, but some patients may achieve the full benefits of a CES treatment within 10 minutes. Many dentists use it instead of nitrous oxide gas to help relax patients during dental procedures.63 Sometimes these dental procedures last for hours with the patient undergoing CES treatment the entire time.

Although CES treatment is indicated for insomnia, because of the increased alertness some patients find it difficult to fall asleep immediately after a treatment. Accordingly, it is recommended that CES be used at least three hours before going to bed. Also, in most cases after daily treatments for the first week or two, treating every other day is usually more effective than daily treatment.

The CES Experience

During the treatment, most patients will experience a subjective change in their body weight. They may feel heavier at first and then lighter, or they may feel lighter initially. The patient may feel worse during the heavy cycle and this feeling can last for hours or even days in rare cases unless extra treatment time is given. Therefore it is important to continue the treatment if the patient feels heavier at the end of the allotted time, even if it has already been 20 minutes or more. Continue for at least two to five minutes after the patient feels lighter. Not all patients will be aware of these weight-perception changes.

Following CES, most people feel better, less distressed, and more focused on mental tasks. They generally sleep better and report improved concentration, increased learning abilities, enhanced recall, and a heightened state of well being.

Psychologists first described these general feelings during the 1970s as an alpha state of consciousness. Meditation, biofeedback training, relaxation instructions, chanting, hypnotherapy, and certain religious rituals also produce such states. This is not the same as the alpha brain wave frequency of 8 to 13 Hz. Often, practitioners are confused by device representatives who claim that their particular device will output and entrain a brain to the alpha frequency. There is no evidence to support that CES devices work on an entrainment principle.


There have not been any significant lasting harmful side effects reported in any of the research literature from either CES. As with all electrical devices, caution is advised during pregnancy, and with patients using an older model (pre-1998) demand-type pacemaker. In addition, it is recommended that patients do not operate complex machinery or drive automobiles during and shortly after a CES treatment.


MET and CES are electromedical modalities that use low level currents that usually do not exceed one milliampere. Beneficial effects have been reported for a wide variety of pain, psychological distress, and addiction-related disorders.

Pain is a complex process encompassing the entire nervous system. To achieve optimal results through electromedical intervention, the peripheral and central nervous systems should both be treated. Cranial electrotherapy stimulation induces a relaxed, alert state. It is a primary modality effective for controlling anxiety, depression, insomnia, and generalized stress ubiquitous in pain patients. In addition, there is mounting evidence that CES can enhance cognitive functions. Because of its safety and effectiveness, the combination of MET and CES used with the protocols described here are highly recommended for a broad range of pain and stress-related disorders.

Last updated on: January 24, 2012
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