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13 Articles in Volume 11, Issue #5
Case Study: Patient With Fibromyalgia And Sleep Apnea
Current Treatments for Phantom Limb Pain
Doctor Shopping
Effective Protocol for the Management of Plantar Fasciitis
Giving Severe and Chronic Pain a Name: Maldynia
Is the New Pain Vocabulary Helping Patient Care?
Medications for Chronic Pain—Other Agents
New Technique Combines Electrical Currents and Local Anesthetic for Pain Management
Pain Management Dilemmas of Sickle Cell Disease
Sleep Apnea in Patients With Fibromyalgia: A Growing Concern
The Essential FDA/PDR Indications and Warnings For Opioid Prescribing
The Role of the Clinician In Determining Disability and Pain
Why Does Acute Postoperative Pain Become Chronic and Can It Be Prevented?

New Technique Combines Electrical Currents and Local Anesthetic for Pain Management

Combined electrochemical nerve block reduced pain in 80% of patients with neuropathies and 50% of patients with intractable back pain.

Numerous types of electrical currents are offered in modern electromedicine. The plethora of currents is made possible by varying the frequency, amplitude (intensity), and direction of the current in time. Within these electric current parameters are distinct and varying physiologic and therapeutic effects for the human biosystem.

Typically, therapeutic electric currents are classified according to their frequencies—for example, low frequency (LF; <2,000 Hz), medium frequency (MF; 2,000-100,000 Hz), or high frequency (HF; >100,000 Hz). This therapeutic classification system appears to originate from numerous physiologic investigations made in the last century.1-5 In the human biosystem, LF and MF currents are used for therapeutic stimulation of excitable cells (receptors, nerves, and muscles). Depending on the stimulating frequency delivered, physiologic and therapeutic actions may occur that may include vasodilatation, vasoconstriction, analgesia, activation of regeneration, and facilitation of metabolism.

This article describes a new electromagnetic device and its use in combination with local anesthetic therapy to treat pain problems.

New Advanced Technology

The vast majority of electromedical devices available in the United States employ LF stimulation (eg, transcutaneous electrical nerve stimulation [TENS]). Balanced MF currents have been developed that produce twice the electrical current with no electrical charge. A new type of electrical current technology has been developed to enhance the stimulating lower frequencies and nonstimulating middle frequencies for increased efficacy in clinical practice. The device also combines, and simultaneously delivers, frequency-modulated (FM) and amplitude-modulated (AM) electric cell currents in the MF range. We refer to this electromedical approach as electronic signal treatment (EST).

This new technology may reach deeper into tissue structures with simultaneous modulation of amplitude and frequency between 2,500 Hz and 33,000 Hz. It is also capable of modulating its MF electric cell-signaling current down into the LF range at available frequency rates between 0.1 and 999 Hz.

In addition, we have combined the new EST with local anesthetic injections (bupivacaine 0.25%) with clinical success. This technique provides a combined (electrical and chemical) nerve block that enhances treatment of a neuropathy or a painful condition (see Tables 1 and 2). According to the Gould Medical

Dictionary, a nerve block is defined as “[t]he interruption of the passage of impulses through a nerve, as by chemical, mechanical, or electrical means.” Because nerve blocks occur at voltage-gated channels, all nerve blocks are essentially electrical. According to Szasz, “There is no such thing as a chemical block … only an electrical block.”6 We refer to this as combined electrochemical block (CEB).

Table 1. What Do Electrical Currents and Local Anesthetics Accomplish?

Clinical Experiences

It is the experience of the authors that pain is reduced by CEB in about 80% of patients who have neuropathies. As shown in Figure 1, 16 patients with neuropathies improved over a course of 20 treatments. The CEB also has worked well in many cases of failed spine fusion syndrome and failed back surgery syndrome. In a small series of patients, more than 50% of those with hardware and intractable pain and proprioception difficulties showed improvement with bilateral transforminal epidural bupivacaine injections along with the application of EST.7 In fact, CEB may be considered a less invasive alternative to spinal cord stimulator implantation.

Average Pain Scores Reduction for 16 Patients with Neuropathies

Case Report

A 73-year-old woman had a 15-year history of low back pain with pain radiation down the legs. Diagnostic studies revealed spinal stenosis and facet arthropathy. She received three CEBs and two ESTs weekly for 3 weeks. After a pause of several days, she received two CEBs and three EST treatments over 2 weeks. At the end of this time, her visual analogue scale pain score had dropped from 10 of 10 to 2 of 10, and she was able to leave her house and walk with her husband.

Electromagnetic Physics of the Body

Why does this work? One major difference between the electric cell-signaling currents in EST and older devices is that EST allows greater depth of penetration through the dermal tissue by overall lowering of impedance to higher-frequency currents. This unique multiplex signaling configuration of mixed higher MF with overriding lower stimulatory frequencies (combined FM and AM signals) allows for the optimum voltage necessary to achieve proper depth of penetration while using lowered therapeutic response frequencies to affect the voltage-gated channels and receptors within target tissue (see Table 2).

Table 2: Nerve Fiber Types and Nerve Blocking

By continually varying the primary medium frequency or using the frequency-modulated signals in a higher range, we can overcome the natural resistance to different tissue structures. Examples of these different resistant values are typically measured in ohms. The lowest resistance (impedance) is, in fact, neural tissue (1,000 Ω), so most (>65%) of the current (energy) will be drawn to the nerves.

Stimulatory effects are defined as the physiologic effects that appear from the use of lower electric current frequencies, which produce repeated action potentials (impulses) in excitable cells (LF). The induced membrane depolarization and subsequent repolarization produce a number of mechanisms of action known to be effective in treatment by varying the stimulation frequency. These include analgesia from the principle of counter-irritation; analgesia from stimulated neuropeptide release (eg, β-endorphin, encephalin); enhanced circulation; sympathetically mediated vasoconstriction (detumescence effects); sympathetically mediated vasodilatation (antispasmodic effects); muscle activation, training, and strengthening; excitation of sprouting nerve axon processes; and an overall influence on the metabolism.8-12

Facilitatory effects are defined as the varied and multiple physiologic effects (biochemical changes) that appear from the use of higher MF electric currents directly or indirectly, but not occurring from the repeated production of any action potentials. There are a number of physiologic changes and biochemical actions that can be seen from the use of these higher MF signals and their resonance components. Examples include analgesia from balancing the metabolite concentration differences (pH); analgesia from second-messenger formation (cyclic AMP [cAMP]-mediated membrane repair processes); analgesia from nerve (pain) fiber blockade via reactive depolarization; vessel vasoconstriction via contraction of the vessel wall smooth muscle; anti-inflammatory activity by activating filtration/diffusion processes;11 edema management, activation of regeneration and support by second messenger formation (eg, cAMP); immune system activation and support via improved intercellular communication; and the general facilitation of metabolism.11-14

These multiplexed and varied medium frequency signals (MFs) have a direct affect on voltage-dependent gates, and the alteration in the membrane physiology is objectively measurable. A number of scientific citations demonstrate both conformational changes in the G proteins of the cell membrane and subsequent second messenger formation (directing cell-specific activity) within the cell at different voltage gates when exposed to frequency and resonance-specific MF electric signal currents.11-18 By electrically blocking the severe pain-firing nerves in patients, we can obtain instantaneous pain suppression (electric nerve block) (see Figure 2).

Electric Nerve Block to the Sciatic Nerve

Avoidance of Nerve Accommodation

The definition of nerve accommodation is the ability of nerve tissue to adjust to a constant source and intensity of stimulation, so that some change in either intensity or duration of the stimulus is necessary to elicit a response beyond the initial reaction. Accommodation is probably caused by reduced sodium ion permeability, which results in an increased threshold intensity and subsequent stabilization of the resting membrane potential.15,19,20 Nerve accommodation breakdown has been documented as a characteristic of electric nerve blocks.21

Unlike other present-day electroanalgesia technologies (eg, TENS, interferential current, MF scanning), it is not possible for the nerve to accommodate during treatment with EST. This is because the specific parameters of the primary MFs, signal lower-modulation frequencies, frequency sweep-step rate, dwell times at each given frequency, intensity of the electric cell signal and harmonic frequencies, and overall type of modulation are constantly changing. The desired parameters to elicit specific mechanisms of physiologic action for treating specific medical conditions are programmed into the treatment algorithms. The constant varying of frequency and intensity are then delivered simultaneously, individually, or alternately to give the body exposure to the greatest number of electric cell-signaling events.

Through the computer-assisted digital manipulation of higher primary EST frequencies at specific intervals, a slower, controlled modulation frequency rate with varied intensities (dosage) is superimposed on the primary frequency. This controlled modulation rate can be varied to match and target types and subsets of ion voltage-gated channels at the cell membrane. It is particularly useful in assisting the abnormal nerve in returning to more steady-state natural firing frequencies.15,22

Physiologic Effects

There are a number of physiologic and therapeutic actions induced by electric currents in treating various medical conditions (see Table 3). They are briefly summarized here.

Table 3: Therapeutic Effects of Simultaneous Variations of Frequency and Amplitute of Electric Currects

Analgesia: Effects on the Diminution of Pain

There are several mechanisms that explain the mechanism of analgesia:

  • Under the influence of rapidly alternating polarity electrical signal energy fields, ion movement is enhanced, and this tends to balance high-concentration differences in metabolites; these effects promote pH normalization and reduction in tissue acidosis;
  • Second messenger formation (cAMP) directs all cell-specific activity toward cell membrane repair, inhibiting arachidonic acid release from insulted membranes and subsequent prostaglandin (pain mediator) cascade;
  • Specific electric signal energy parameters produce repeated excitation of afferent nerve fibers, affecting neuronal signaling processes in the central nervous system (CNS) and interfering with local pain perception (gate-control theory);
  • Electric cell signaling assists in cell receptor uptake of β-endorphin, encephalin, and phyllokinin, which modulate or inhibit pain impulses in the CNS; and
  • The application of higher-dose, higher-frequency EST electric cell signals fall within the absolute refractory period of the cell membrane, inducing a sustained depolarized state across multiple nodes of Ranvier and inhibition (block) of axon information (pain signal) transport. 11-15,19,20,23-25

Circulatory and Lymphatic Flow

Signaling cAMP leads to the opening of voltage-gated channels in efferent C-fibers of pain neurons and the sympathetic nervous system. Specific parameters of electric cell-signaling energy cause a fatiguing response, which induces sympathetically mediated vasodilatation (after brief vasoconstriction) via the depletion of the synaptic neurotransmitter (norepinephrine). Vessels then vasodilate, which increases local circulation to allow incoming nutrients and the flushing out of metabolic waste products. This cascade will help to eliminate the primary biochemical cause of local pain (peripheral sensitization). In addition, signaling cAMP leads to decreased afferent C-fiber firing, which in turn decreases ephaptic cross firing of afferent A-δ fibers. Use of cAMP by opening voltage-gated channels can likely produce physiologic normalization.12-15,26

Edema Reduction

The multiple mechanisms of action that are induced by varied EST electric cell signaling energy actively promote management of edema, including edematous tissue repair, enhanced filtration and diffusion processes, and pain and inflammation mediator redistribution. Mechanisms include specific vasoconstrictive EST electric cell-signaling frequencies that enhance centripetal transport of venous blood and lymph via sympathetic stimulation.

Increased Metabolism

EST energy triggers cAMP from increased adenosine triphosphate (ATP) production and improves cell respiration via ion transport (membrane permeability). EST energy produces a hormone-like effect by triggering an electrical conformation change to the cell membrane G protein. This influences adenylate cyclase activity, resulting in the formation of the second messenger cAMP, which is known to direct cell-specific activity, including cellular repair processes. cAMP-induced repair processes are necessary to stabilize (normalize) the cell membrane and inhibit continued leakage of acids known to trigger pain and inflammation mediators.27 This process may play the most critical role toward normalization of cell function.11,13,15,28,29

Regeneration of Tissue

Specific parameters and dosage of stimulative EST frequencies will produce a response inducing excitation of sprouting axon processes at three to five times the normal regeneration rate of 1 to 3 mm per day via repeated action potential propagation (maximum neuron signaling without neurotransmitter depletion).30,31

Muscle Stimulation, Activation, and Facilitation

Specific MF EST electric cell signals can be employed at higher than the motor firing threshold to activate muscle fibers directly via sustained depolarization with minimal motor neuron involvement.

Specific LF stimulative EST electric cell signals can be employed to activate the oxidative muscle metabolism and enzyme synthesis for better oxidative metabolic adaptation, contractile substance increase, and improved capillary regeneration (neovascularization). Neuromuscular effects include imitative activation, endurance training, thrombosis prevention, strengthening, and relaxation (spasmolysis).

Immune System Support

EST electric cell-signaling energy appears to improve and support the immune system by improving gap-junction intercellular communication. Gap junctions are protein-lined channels that directly link the cytosol of one cell with another adjacent cell, providing a passageway for movement of very small molecules and ions between the cells.26,30-32

EST energy influences the electrically charged ion movements through gap junctions by increasing the transport through the cell to cell canals and by facilitating intercellular electric and chemical communication and metabolic cooperation.11,26,33 EST energy fields contribute to a functional improvement in tissues that are dysfunctional—for example, in the healing phase of injured tissue and in degenerative tissue changes, metabolic conditions, edema, and areas of regional insulted tissue.

Anti-inflammatory Effects

EST energy works through specific biosystems and their controls via multiple mechanisms (listed above) by causing initial inflammation facilitation and then quick resolution of the inflammatory process, preventing it from leading to chronic inflammation and chronic pain.11


Extensive use over the past 15 to 20 years has established a very low risk profile of treatment with electric currents, even with these complex waveforms. The addition of local anesthetic blocks adds only an incremental risk (for infection). In the personal experience of one of the authors, the only adverse effect noted among a few hundreds patients was slightly increased pain, probably due to over-stimulation or excessive electric signal energy (dosage), easily corrected in subsequent treatments. We also had one minor (first-degree) burn due to excessive application of electric signal energy (power density) to a poorly hydrated adhesive electrode. The burn resolved itself without additional medical intervention. The chances for increased expenses to the patient and third party payers treated with EST because of iatrogenic consequences are minute.


History has clearly shown that electric current devices have treatment merit. In most cases, electrical devices have, unfortunately, been proven to produce temporary patient improvement. It is now evident that complex, painful conditions need more than one treatment modality or an alternation of multiple and different mechanisms of action to sustain long-term patient treatment success.

We believe that longer-lasting outcomes can be achieved by using AM and FM currents at prescribed MF and LF parameters. When combined with a local anesthetic blocking agent, better results can be obtained. This procedure combines the positive benefits of intermittently generated membrane sustained depolarization, interruption of the pain signal along the axon, normalized second messenger (cAMP) levels, β-adrenergic response, circulatory vasodilatation, general relaxation effects, and endogenous opiate release. The combined use of electric currents and local anesthetic should be more widely investigated in clinical practice.

Notes: The device employed in this review was the NeoGen-Series available through Sanexas Corporation, Las Vegas, NV.

Last updated on: September 21, 2011
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