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Evaluation of Antiemetic Pharmacotherapy in the Setting of Opioid Withdrawal

As the dose of opioids used for chronic pain management decreases, patients who are put on a weaning program may experience withdrawal symptoms. Ondansetron, a well-known antiemetic, may be a safe and effective option for managing these symptoms.
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Conclusion

When choosing an antiemetic for the management of opioid withdrawal symptoms, clinicians should be cognizant of the safety, efficacy, and abuse potential of each therapy. Considering available literature, ondansetron appears to be preferred over dopamine-receptor antagonists in the treatment of opioid withdrawal symptoms, but evidence is lacking, and further investigation is warranted.

Last updated on: December 27, 2016
First published on: December 1, 2016
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