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All Neuropathic Pain Articles

Carpal tunnel syndrome is the most common and widely studied nerve entrapment syndrome, accounting for 90% of all such disorders.1 The syndrome is caused by compression of the median nerve as it travels through the wrist at the carpal tunnel.2 Patients with carpal tunnel syndrome (CTS) may experience pain and paresthesia in the distribution of the median nerve, which inclu
Trigeminal neuralgia (TN) is the most frequent type of facial pain, with a worldwide incidence ranging from 12.6 per 100,000 annually to 27 per 100,000 annually.1 TN is usually divided in two subtypes:
Pain and pain-related illness, as well as beliefs about pain, had a limiting effect on the ability of individuals with multiple sclerosis (MS) to engage in activities, based on data from 161 adults with MS who reported at least mild pain.
Any immune disorder increases the risk of SARS-CoV-2virus and COVID-19 illness. The most prevalent immune disease is diabetes. Type 2 diabetes and obesity have increased worldwide to epidemic proportions and, together, are deadly contributors to the COVID-19 pandemic. Obesity and type 2 diabetes also are important factors in the management of chronic pain disorders.
Emerging gene therapy may reduce pain associated with diabetic neuropathy and offer an alternative to opioid use.
The authors share their clinical experience in assessing and treating chronic pelvic pain (CPP) based on the presentation of complex regional pain syndrome (CRPS) characteristics, including response to nerve blocks and stimulation.
Pharmacologic options for the treatment of phantom limb pain, including gabapentin, TCAs, opioids, ketamine, memantine, lidocaine, and bupivacaine.
The cream may reduce pain and improve motor function in patients with CRPS.
The clinical state of overlapping pain conditions among patients with chronic pain is often overlooked.
The pathophysiology of approaches to 3 commonly seen pain conditions: Complex Regional Pain Syndrome, Ehlers-Danlos Syndrome, and Small Fiber Neuropathy.
Both pharmacological and non-pharmacological therapies show promising results in patients with shingles.
Researchers pinpoint the biology of underlying pain associated with mechanical allodynia
New research shows mechanisms for THC in cannabis for chronic nerve pain treatment.
Patients with Type 2 diabetes and painful diabetic peripheral neuropathy were found to have low vitamin D levels compared to healthy subjects.
A series of case studies help to better understand types of non-cancer-related centralized pain conditions.
The impact of peripheral neuropathy on quality of life and hopes for future treatment options.
In patients with PDN, greater pain intensity leads to poorer quality of life, sleep, function, and work productivity.
When diagnosing peripheral artery disease, a common condition in people with diabetes, leg pain may arise from intermittent claudication and ischemia.
Jim Broatch, executive vice president and director of the Reflex Sympathetic Dystrophy Syndrome Association, advocates for a multidisciplinary approach to pain management for patients with complex regional pain syndrome.
Emerging research on pain treatment for complex regional pain syndrome, a debilitating neurological pain syndrome.
Learn how decompression surgery can help relieve and reverse symptoms (tingling, numbness, pain) of diabetic neuropathy of the foot.
Controlling type 1 and type 2 diabetes is the most effective way to prevent diabetic neuropathy. When treatments are needed, however, there are a number of promising options.
Learn more about the symptoms, diagnosis, and pain treatment of HIV-related neuropathies.
The definition, incidence, diagnosis, and treatment of thoracic outlet syndrome (TOS) are somewhat controversial.
Meralgia paresthetica (MP), a common condition seen by both primary care physicians and specialists, is easily misdiagnosed because it can mimic other disease processes. Often, merely the awareness of the condition and knowledge of a few key differentiating factors helps the clinician quickly recognize this disorder.
Eight months ago, a patient developed diabetic neuropathy. He is now complaining of a severe burning sensation, pain, and numbness in both lower limbs. He currently is taking pregabalin (Lyrica) at 150 mg bid and duloxetine at 60 mg bid.
Complex regional pain syndrome (CRPS) often has baffled the medical community. However, improved knowledge of pro-inflammatory cytokines and central sensitization of pain are unraveling some of the secrets behind CRPS.
Chronic pain is a common problem in the community and major source of healthcare utilization in the United States.
Assessment of neuropathic pain begins with a thorough neurologic history, addressing the nature and onset of pain symptoms and underlying etiologic factors.
Peripheral artery disease is common in patients with diabetes. Proper prevention and early diagnosis can help patients avoid painful neuropathies and lower-extremity amputations.
Occupationally induced carpal tunnel syndrome is a reactive condition that responds quickly to offending movements, and symptoms can manifest within minutes of beginning activity in those susceptible individuals. Those symptoms correlate well with median nerve swelling, which can be detected using ultrasound.
Similar to carpel tunnel syndrome surgery, nerve decompression surgery helps improve symptoms of DPN of the foot and prevents amputation.
By combining medication management with interventional and non-interventional therapies, patients with CRPS can often dramatically reduce their symptoms and lead full and functional lives.
Trigeminal neuralgia is a relatively common neuropathic disorder that is characterized by sudden severe episodes of lancinating or electric pain along the distribution of cranial nerve V (CNV).
In-depth article discusses the etiology and differential diagnosis of trigeminal neuralgia.
Article describes symptoms, diagnosis, and treatment of carpal tunnel syndrome, one of the most common pain conditions seen in clinical practice.
Letter to the Editor of Practical Pain Management about human chorionic gonadotropin (HCG) in the treatment of diabetic peripheral neuropathy.
Centralized pain is fast emerging as a critical factor in therapeutic, diagnostic, and medical-legal issues. It's crucial to know how to diagnose central pain; learn from a leader in the pain field.
Neuropathic pain has a number of forms or diagnoses, but possibly the most difficult to understand and treat is central neuropathic pain (CNP). Article from a pain medicine specialist on classic central pain syndromes, including multiple sclerosis and phantom limb pain.
A pain management specialist answers the question: What is a basic formula for treating neuropathic pain? Reviews diabetic neuropathy treatments, including first-tier and second-tier medications.
In an open-label trial, a unique electric current combined with a local anesthetic reduced pain in patients who have diabetic neuropathy. Read up on the results in this neuropathy research study.
Diabetic neuropathy is a common complication of type 1 diabetes and type 2 diabetes, associated with duration of the disease and duration of hyperglycemia. Article covers treating the painful symptoms of diabetic neuropathy.
For many people with single- and multiple-limb amputations, pain does not cease following amputation. Article covers current treatments.
Diabetes mellitus is the leading cause of peripheral neuropathy. This article focuses on the epidemiology and pathogenesis as well as clinical features, diagnosis, and management of DSPN, the most common form of diabetic neuropathy.
Although there is limited data in published guidelines on the use of opioids to treat neuropathic pain, several reports suggest that certain unique opioids might be useful in this setting. This article explores those unique opioids.
A review of the diagnosis, evaluation, and treatment of diabetic peripheral neuropathic pain.
This article discusses treatment of neuropathic pain in multiple sclerosis and explains how patients demonstrated improvement using the oral synthetic cannabinoid nabilone.
Initial treatment of musculoskeletal and neuropathic pain can be more effective by incorporating combination pharmacologic alternatives as adjuncts to oral or parenteral analgesic medication.
Read this personal account of life with reflex sympathetic dystrophy (RSD), and one writer's journey to regain control of her life.
While Lidoderm is currently FDA-approved only for the pain associated with postherpetic neuralgia (PHN), Phase IV studies suggest that Lidoderm has potential utility in a variety of chronic pain syndromes.
Understanding the organic and physiological patterns of referred pain helps to identify the true origin of pathology and inform proper treatment.
Characterized by hand and wrist pain, carpal tunnel syndrome is a symptomatic distal median nerve neuropathy at the wrist and is the most commonly encountered entrapment neuropathy.
The workshop was organized by Mark S. Cooper, PhD (Univ. Washington); Donald C. Manning, MD, PhD (Shionogi USA, Inc.); and Kirk W. Johnson, PhD (MediciNova, Inc). 
Acute herpes zoster neuritis and postherpetic neuralgia continues to be one of the most painful, acute and chronic conditions to afflict mankind. It will continue to be a major health problem as the baby-boomer generation in the United States ages and is at risk for the reemergence of the varicella zoster virus.
Arguably the major scientific research finding in the Decade of Pain is that severe pain causes rearrangement or reconfiguration of nerve cells in the central nervous system.1-8 This rearrangement or transformation, called neuroplasticity, is a response to electronic impulses that arise from a peripheral pain site that is not healed by the body’s basic immune response to a painful in
More than 40% of multiple sclerosis (MS) patients experience at least one type of pain. Learn more about diagnosing and treating MS patients with pain.
Donald R. Eck, DO writes about a non-surgical treatment option for carpal tunnel syndrome.
The use of laboratory studies and imaging studies in the diagnosis of neuropathic pain present clinical challenges and, although medications remain the mainstay of therapy, it is frequently necessary to try multiple different medications and modalities for adequate treatment.
Shingles pain and lesions resolved in 48 hours after treatment with frequency-specific microcurrent. Learn about this non-pharmacologic treatment of shingles.
Progress in understanding the pathophysiology of complex regional pain syndrome (CRPS: used to be called RSD or causalgia) is leading to new and more effective treatments.
Patients with Complex Regional Pain Syndrome commonly describe a diverse range of sensory and motor problems. These include pain to touch or the threat of touch, temperature, color and sweating abnormalities, problems in initiating movement and reduced function.
CRPS (which used to be called RSD) is a chronic pain condition. Overview from a pain management specialist to help doctors better understand and treat CRPS.
Laser therapy can be easily and economically used in the treatment of both acute phase herpes zoster and in chronic post-herpetic neuralgia.
A report of three unexplained, severely-disabling pediatric cases, in otherwise healthy children, successfully treated with long term anti-viral therapy.
Article discusses a pain patient that presents with postherpetic neuralgia and multiple musculoskeletal issues, which provides an interesting and challenging case study.
A discussion of the pathophysiology of neuropathic pain and an overview of the modalities used to alleviate it.
Low-level consumption of glutathione-enhancing micronutrients may be beneficial in relieving symptoms of peripheral neuropathy of unknown origin.
Results and implications of this increasingly utilized option for the treatment of refractory CRPS.
Background, diagnosis, discussion, and case report of successful management of postherpetic neuralgia (PHN) pain in an elderly patient using laser acupuncture.
Case reports from 2 patients whose unrelenting facial pain and hypersensitivity from their diagnosed trigeminal neuralgia was resolved with low-level laser therapy.
Learn the basics of complex regional pain syndrome (CRPS, also called RSD), including common treatments and the importance of patient education.
Article highlights the first level of evaluation for diagnosing the chronic pain patient with chronic regional pain syndrome (CRPS) using the multilevel method of diagnosis Practical Application of Neuropostural Evaluations (P.A.N.E.) process.
Carpal tunnel syndrome continues to be a vexing problem occupationally in industry and in the general medical population as well.
A case report of a patient successfully mimicking the signs and symptoms of reflex sympathetic dystrophy (RSD) together with a review of what is currently known about RSD presentation, epidemiology, and pathophysiology.
Pain management challenge in diagnosing and treating a rare case of phrenic nerve palsy in combination with cervical facet joint pain in a diabetic patient.
Near infrared light therapy, together with physical therapy, may be able to reduce pain in neuropathy patients and possibly reduce medication dosage levels of those undergoing drug therapy.
Under-consumption or lack of critical nutrients in the diets of diabetics may be implicated in diabetic complications including neuropathy.
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