Practical Pain Management Community Advice

I am searching for treatment options for a mid back burning pain in my spine that escalates as the morning wears on. Relief is only provided if I lay down or use hydrocodone. When I was actively being poisoned (from our exterminator contaminated home), my spine would collapse and I wouldn't be able to sit upright but had to lay across a table or lay down entirely to function. MRI etc shows 'normal' aging (female soon to be 69) but I have not been able to discover information on the burning pain and what to do about it. Any help appreciated. This site has already been very helpful in discussing the P450 influence on hormones and the endocrine system and how they might be involved.

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60 /post polio sequalae...Sorry to read the despair however its about finding relief by asessing the muscle bundle that KEEPS THE SPINE ALIGNED...
Are your mid back muscle out of condition and burning because of streaching as mine do ..Well its a matter of moving in safe moves to build strength..have you been favoring this condition too long.maybe its time to use an electronic muscle ecerciser or stimulator to contract only that bundle that parallels the spine??Go through a couple weeks of careful strengthening routines and feel it resede the condition. Then be sure to achieve a more active routine with your stimulator.Its interesting learning about rehab with electronics and such.Then once youve got better results from you exercise routines go out into lifes gardens and become satisfied that you CAN HANDLE WHAT LIFE DEALS OUT...


Is this good advice?

Hi there redhen,

It's been almost four years since you made this post so I don't know if you are still around, but your symptoms sounded very much like those of someone with pseudocholinesterase deficiency. This is an enzyme the body makes to break down acetylcholine, one of the body's primary neurotransmitter signalling chemicals.

Some people have a genetic mutation causing them to make very little pseudocholinesterase, which makes them vulnerable to drugs, organophosphate pesticides, and the natural glycoalkyloid pesticides in the leaves and fruit of nightshade plants. These substances are cholinesterase inhibitors -- they further reduce or inhibit the action of the enzyme, and they build up in body tissues (fat, connective tissue, and bone). This causes "cholinergic excess" -- too much acetylcholine and all it's attendant symptoms.

What does this look like? Abdominal cramps, diarrhea, insomnia, chest tightness, rapid heartbeat, sweating, tinnitus, migraine, hyperaccusis, light sensitivity, muscle spasms, muscle/fascial stiffness, joint pain, muscle weakness, myopathy, neuralgia, loss of deep tendon reflexes, tendonitis, exercise intolerance, sciatica, back pain, neck pain, TMJ...all depending on previous injuries and current activities.

Basically, any tissue with a higher proportion of acetylcholine receptors is going to be negatively effected -- organs, muscles and tendons associated with the fight or flight response: balance muscles/tendons in your feet, legs, back and neck especially. The molecules in glycoalkyloids are the same shape as acetylcholine and bind to the ACh receptors -- essentially turning cells on. But if you don't make enough cholinesterase, you can't break them down and turn those nerve, bone, muscle or tendon cells off. They essentially go crazy, then burn themselves out. So, first muscle spasms, then muscle weakness as the cells fry and that feeling like "my spine would collapse". The burning pain could be neuropathy from glycoalkyloids destroying nerve cells, or muscle overuse pain from toxic muscle cells or muscles cued by compromised nerve cells, or both.

If pseudocholinesterase deficiency is the cause of your problem, you can radically improve your situation by avoiding eating ALL nightshades (potatoes, tomatoes, eggplant, peppers, paprika, chili powder, potato starch, nicotine) and taking any cholinesterase inhibiting drugs. Chronic exposure to organophosphate pesticides could be enough by itself to cause the problem, but you can do a genetic test via 23andMe, upload your raw data to Promethease, and find out if you have any of the genetic mutations that reduce your production of pseudocholinesterase or acetylcholinesterase.