Relieving the pain of the acute attack and reducing the incidence for gout becoming chronic are the foremost goals of treatment.
Relieve the pain of the acute attack
Non-steroid anti-inflammatory drugs (NSAIDs) have been around for a long time (eg, indomethacin). However, it is advised to recognize NSAIDs can thin the blood and affect renal function. Many patients cannot take NSAIDs and colchicine may be prescribed. Other treatments offered are oral steroids (eg, Medrol Dosepak) or an injectable corticosteroid. It can take a few days to a couple of weeks for gout pain to be completely eliminated.
The biochemical basis of the acute inflammation in gout has been determined, and a cytokine called IL1-beta. Current research into IL1-beta inhibitors are in development as a subcutaneous injection. One product offers continuous relief up to three months in a single injection without renal effects.
Chronic gout: reducing the incidence
After the initial attack of gout is treated, it can be years before it reoccurs. When it does reoccur, the frequency and severity of pain will increase. The treatment goal is to reduce the level of uric acid. However, treatment using allopurinol is prescribed after the gout attack has completely resolved. Then titrate up until the serum uric acid is 6 (current target).