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Personality Disorders in Migraineurs

With a higher than normal prevalence of moderate or severe personality disorder in this population, recognizing the disorder allows alteration of both goals and approach.
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Personality disorders (PD) are currently categorized as Cluster A (paranoid, schizoid, schizotypal), Cluster B (antisocial, borderline, histrionic, narcissistic), and Cluster C (avoidant, dependent, obsessive-compulsive).1 Many people possess a number of characteristics of more than on PD, and are not easily categorized into one specific PD. This study was undertaken to assess the prevalence of moderate or severe PDs within a chronic headache population. It is crucial to recognize PD patients, as the approach and treatment needs to be modified. Recognition of the more ‘dangerous’ PDs is also important in order to protect the healthcare providers. Left unrecognized, certain PDs (paranoid, antisocial, borderline (BPD), narcissistic) increase the risk for legal and regulatory problems. In addition, on rare occasions, there may be threats of physical violence as well. For both the patient’s and the healthcare worker’s wellbeing it is important to be cognizant of PD characteristics.


This screening study assessed one thousand consecutive migraine patients at one headache clinic for Axis II Personality Disorder (PD) pathology. The purpose was to determine the prevalence of moderate or severe PD within a headache population.


One thousand long-term patients at the author’s headache clinic were evaluated, all presenting with the International Headache Society diagnosis of migraines.2 The patients had been treated at the clinic for a minimum of six months; the only exceptions—where patients were treated for less than six months—were four patients who were dismissed quickly from the practice. 805 women and 195 men, ages 20 to 92, were evaluated.

The patients had completed a psychiatric screening intake form, and were interviewed by the treating neurologist (and psychopharmacologist). Charts were reviewed for the purposes of this study.

The diagnosis of PD was done in accordance with the DSM-IV criteria.3 For this study, patients with ‘PD characteristics’ but not fully fulfilling DSM-IV criteria were excluded. Only the patients deemed to exhibit moderate-to-severe PD psycho-pathology were included. The PD characteristics were pervasive, longstanding, and greatly influenced social and work functioning. The purpose of this was twofold: 1) to identify patients at risk to themselves (and the healthcare providers), and 2) to exclude those with marginal PD diagnoses.

General characteristics of each PD are as follows: • paranoid (suspicious, rigid, thin-skinned, angry, dangerous, doubt loyalty); • schizoid (self sufficient, indifferent, detached); • schizotypal (eccentric, grandiose); • antisocial (exploitative, condescending, opportunistic, deceitful, impulsive, irritable, lack of remorse); • borderline (instability, poor self image, abandonment fears, impulsive, suicidal, splitting, angry, depressed, dramatic); • histrionic (expressive, attention-seeking, emotional, shallow, theatrical, needy, seductive, childlike, exaggerated, body-oriented); • narcissistic (grandiose, lacks empathy, needs admiration, condescending, sense of entitlement, exploitative, envious, arrogant, selfish, uncaring, rageful, insensitive); • avoidant (socially inhibited, inadequacy, hypersensitive, fearful, sad, hypervigilant); dependent (submissive, clings, fear of separation, need reassurance, manipulative, naive, lack of confidence); and • obsessive-compulsive (rigid, preoccupied with orderliness, miserly, perfectionistic, indecisive, cold, hoarding, controlling, anxious, workaholic, demanding).


In this screening study, 5.5% of migraineurs had a moderate or severe PD. The most commonly observed PDs were borderline personality disorder (BPD) (1.2%) and avoidant(1.1%). See Table 1 for a summary of results.


Personality disorders are not discussed as extensively as Axis I disorders (anxiety/ depression/substance abuse). The reasons for this include the lack of funding for research (there are no specific drugs for Axis II), and the difficult nature of the patients. However, PD in pain or headache patients is an important phenomena, as the psychiatric illness often goes unrecognized or misdiagnosed. This leads to inappropriate treatment, and also may place the healthcare provider at risk. The increased risks associated with dealing with certain PD patients include legal (malpractice), regulatory (an increase in letters to hospital boards and state departments of regulation), and physical (threats or acts of violence).

The differential diagnosis usually includes separating Axis II from bipolar disorder, post-traumatic stress disorder, major depression with anxiety, or dys-thymia. PD may certainly be comorbid with these conditions.

We currently have a rather rigid categorical listing of PDs in DSM-IV. DSM-V will probably be more dimensional and less categorical, possibly with a ‘spectrum approach.’ Many PDs do not easily fit into one category, but are a combination of several cagtegories.

The etiology of PDs remains controversial, but certainly has a biological basis. Genetics plays a role. A number of theories, such as early over-attachment or detachment with parents, or childhood trauma, have not been validated. Most likely, PD is a genetically-based biological illness that may be expressed after exposure to environmental influences.4 A genetic make-up that leads to a higher degree of resilience—in particular, two long arms of the serotonin transporter gene—may be protective against developing a severe PD.

One previous study on borderline personality disorder (BPD) concluded that BPD comorbid with migraine is associated with increased disability.5 In addition, there were more women with BPD, a higher degree of medication-overuse headache, and headaches were more pervasive among those with BPD. There was a higher degree of depression reported among those with BPD, more unscheduled visits for acute headache treatment, and a lesser chance of adequate response to headache medications. Those with BPD were more severely affected by the headaches, and more likely to be refractory to treatment.5 Another study indicated that the incidence of BPD was increased in migraineurs.6 There is ample evidence that transformed migraine is associated with more prevalent psychopathology—including PD—than is episodic migraine. BPD itself is the mental health equivalent of chronic pain. The two most important prognostic indicators for those with a PD are impulsivity and substance abuse.

Last updated on: December 22, 2011
First published on: January 1, 2009